UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC50 values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, F876L-AR, and W741L-AR, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.
Molekulargewicht:
356.27
Reinheit:
98.09
CAS Nummer:
[2168525-92-4]
Formel:
C15H12F4N4O2
Target-Kategorie:
Estrogen Receptor/ERR
Anwendungsbeschreibung:
Reference compound
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