(1S,9R)-Exatecan (mesylate), CAS [[2938875-54-6]]

Produktübersicht

• Artikelname: (1S,9R)-Exatecan (mesylate), CAS [[2938875-54-6]]
• Artikelnummer: MCE-HY-13631I
• Hersteller Artikelnummer: HY-13631I
• Alternativnummer: MCE-HY-13631I-25MG,MCE-HY-13631I-100MG,MCE-HY-13631I-10MG,MCE-HY-13631I-50MG,MCE-HY-13631I-5MG,MCE-HY-13631I-10MMX1ML
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: (1S,9R)-DX8951f

Produktbeschreibung

(1S,9R)-Exatecan mesylate ((1S,9R)-DX8951f) is a non-prodrug camptothecin derivative and a topoisomerase I inhibitor (IC50=0.975 µg/mL in mice and 0.82 µg/mL in humans). (1S,9R)-Exatecan mesylate blocks enzyme activity and induces apoptosis by stabilizing the enzyme-DNA cleavable complex. (1S,9R)-Exatecan mesylate not only effectively inhibits the proliferation of various malignant tumor cells and tumor growth, but also circumvents P-glycoprotein-mediated multidrug resistance. (1S,9R)-Exatecan mesylate is widely used in preclinical studies of various cancers such as pancreatic cancer, lung cancer, breast cancer, and leukemia[1][2].The chiral isomer of (1S,9R)-Exatecan mesylate is (1R,9R)-Exatecan mesylate (HY-13631J).

Produkteigenschaften

• Molekulargewicht: 531.55
• Reinheit: 98.48
• CAS Nummer: [2938875-54-6]
• Formel: C25H26FN3O7S
• Target-Kategorie: Apoptosis,Drug Derivative,Topoisomerase

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound