NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection[1].
Molekulargewicht:
584.72
Reinheit:
98.11
CAS Nummer:
[469863-16-9]
Formel:
C33H40N6O4
Target-Kategorie:
Parasite,Phosphodiesterase (PDE)
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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