MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. MSA-2 shows EC50s of 8.3 and 24 µM for human STING isoforms WT and HAQ, respectively. MSA-2 stimulates interferon-beta secretion in tumors, induces tumor regression with durable antitumor immunity, and synergizes with anti-PD-1 in syngeneic mouse tumor models[1][2].
Molekulargewicht:
294.32
Reinheit:
99.81
CAS Nummer:
[129425-81-6]
Formel:
C14H14O5S
Target-Kategorie:
STING
Anwendungsbeschreibung:
MCE Product type: Reference compound
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