NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC50 value of 0.79 nM, a Ki value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate (IP) accumulation, Ca2+ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases[1].
Molekulargewicht:
495.49
Reinheit:
98.65
CAS Nummer:
[352290-60-9]
Formel:
C27H24F3N3O3
Target-Kategorie:
GnRH Receptor,PERK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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