WH-10417-099 is a CRBN-type PROTAC multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). WH-10417-099 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) PI3Kgamma ligand 1 (HY-168319), the E3 ubiquitin ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547) and the PROTAC linker (black part) Amino-PEG5-C2-acid (HY-115384). The E3 ligase ligand and linker can form a conjugate Pomalidomide 4-PEG5-acid (HY-131647).
Molekulargewicht:
1039.16
Reinheit:
98.14
CAS Nummer:
[2769753-42-4]
Formel:
C52H62N8O13S
Target-Kategorie:
PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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