5-Monobutyl methotrexate, CAS [[66147-31-7]] Preis auf Anfrage

Produktübersicht

• Artikelname: 5-Monobutyl methotrexate, CAS [[66147-31-7]] Preis auf Anfrage
• Artikelnummer: MCE-HY-137357
• Hersteller Artikelnummer: HY-137357
• Alternativnummer: MCE-HY-137357-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: NSC 305986, gamma-MBMTX

Produktbeschreibung

5-Monobutyl methotrexate (NSC 305986, gamma-MBMTX) is a dihydrofolate reductase (DHFR) inhibitor and esterase substrate. 5-Monobutyl methotrexate is hydrolyzed by esterases to produce methotrexate. In rhesus monkeys, 5-Monobutyl methotrexate clears more slowly from cerebrospinal fluid than from serum, and its serum protein binding rate exceeds 99%. At the same dose rate, 5-Monobutyl methotrexate achieves cerebrospinal fluid concentrations comparable to those of Methotrexate (HY-14519), and exhibits activity against Methotrexate-resistant cells (with transport defects) that is comparable to that against sensitive parental cells. 5-Monobutyl methotrexate can be used in studies related to Methotrexate-resistant tumors[1].

Produkteigenschaften

• Molekulargewicht: 510.55
• CAS Nummer: [66147-31-7]
• Formel: C24H30N8O5
• Target-Kategorie: Dihydrofolate reductase (DHFR)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound