CG428, CAS [[2412055-93-5]]
Artikelnummer:
MCE-HY-137465
| Artikelname: |
CG428, CAS [[2412055-93-5]] |
| Artikelnummer: |
MCE-HY-137465 |
| Hersteller Artikelnummer: |
HY-137465 |
| Alternativnummer: |
MCE-HY-137465-25MG,MCE-HY-137465-10MG,MCE-HY-137465-5MG,MCE-HY-137465-1MG |
| Hersteller: |
MedchemExpress |
| Kategorie: |
Biochemikalien |
| CG428 is a potent and selective tropomyosin receptor kinase (TRK) PROTAC degrader that has anti-tumor activity. CG428 reduces levels of the tropomyosin 3 (TPM3)-TRKA fusion protein in KM12 colorectal carcinoma cells (DC50 = 0.36 nM) and inhibits downstream PLCgamma1phosphorylation (IC50 = 0.33 nM). CG428 has a higher binding affinity for TRKA than TRKB and TRKC (Kd = 1 nM, 28 nM and 4.2 nM, respectively). In addition, CG428 effectively inhibits KM12 cell growth (IC50 = 2.9 nM)[1].(Pink: TRK inhibitor (HY-118271), Black: linker (HY-W067489), Blue: CRBN Ligand (HY-41547)) |
| Molekulargewicht: |
814.86 |
| Reinheit: |
98.26 |
| CAS Nummer: |
[2412055-93-5] |
| Formel: |
C43H43FN10O6 |
| Target-Kategorie: |
PROTACs,Trk Receptor |
| Anwendungsbeschreibung: |
MCE Product type: Reference compound1 |
