(E/Z)-Florzolotau ((E/Z)-APN1607) is a mixed configuration or unspecified configuration of Florzolotau (HY-137557). Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used for the detection of Alzheimers disease (AD) and other tau proteinopathies. Its binding sites are located in the beta-sheet of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein, as well as in the C-shaped cavity of SFs. In addition, APN-1607 binds to intraneuronal inclusions in Alzheimers disease (AD), primary age-related tauopathy (PART) and posterior cortical atrophy (PCA). Florzolotau shows promise for PET imaging studies of neurological disorders, particularly tau proteinopathies[1].
Molekulargewicht:
385.46
Reinheit:
98.01
Formel:
C20H20FN3O2S
Target-Kategorie:
Tau Protein
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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