6-Thioguanine (Thioguanine, 2-Amino-6-purinethiol) is an anti-leukemia and immunosuppressant agent, acts as an inhibitor of SARS and MERS coronavirus papain-like proteases (PLpros) and also potently inhibits USP2 activity, with IC50s of 25 µM and 40 µM for Plpros and recombinant human USP2, respectively.