NS8593 is an SK channel (small conductance Ca2+-activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3). NS8593 inhibits all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 µM, respectively, at 0.5 µM Ca2+). NS8593 does not affect the Ca2+-activated K channels of intermediate and large conductance (hlk and hBK channels, respectively). NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) (IC50 = 1.6 mM). NS8593 can be used for the study of central nervous system (CNS) related diseases[1][2].
Molekulargewicht:
263.34
CAS Nummer:
[875755-39-8]
Formel:
C17H17N3
Target-Kategorie:
Potassium Channel,TRP Channel
Anwendungsbeschreibung:
MCE Product type: Reference compound
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