YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 µM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model[1].
Molekulargewicht:
398.84
Reinheit:
98.01
CAS Nummer:
[423145-35-1]
Formel:
C21H19ClN2O4
Target-Kategorie:
Apoptosis,HSP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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