Ro 31-8220 (mesylate), CAS [[138489-18-6]]

Produktübersicht

• Artikelname: Ro 31-8220 (mesylate), CAS [[138489-18-6]]
• Artikelnummer: MCE-HY-13866
• Hersteller Artikelnummer: HY-13866
• Alternativnummer: MCE-HY-13866-50MG,MCE-HY-13866-10MMX1ML,MCE-HY-13866-100MG,MCE-HY-13866-5MG,MCE-HY-13866-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: Ro 31-8220 methanesulfonate, Bisindolylmaleimide IX mesylate

Produktbeschreibung

Ro 31-8220 mesylate is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCalpha, PKCbetaI, PKCbetaII, PKCgamma, PKCepsilon and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and GSK3beta (IC50s, 3, 8, 15, and 38 nM, respectively), with no effect on MKK3, MKK4, MKK6 and MKK7. Ro 31-8220 mesylate can also inhibit the expression of MKP-1, induce the expression of c-Jun, and activate JNK, and these effects possess pharmacological properties independent of PKC[1][2][3][4][5].

Produkteigenschaften

• Molekulargewicht: 553.65
• Reinheit: 99.57
• CAS Nummer: [138489-18-6]
• Formel: C26H27N5O5S2
• Target-Kategorie: JNK,PKC

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound