KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 has the ability to inhibit cocaine-induced hyperlocomotor activity and sensitization. KVA-D-88 selectively inhibits PDE4B and reduces cAMP degradation, thereby modulating neuroadaptive responses. KVA-D-88 can be used in the study of cocaine addiction[1].
Molekulargewicht:
382.19
Reinheit:
99.81
CAS Nummer:
[2410550-31-9]
Formel:
C17H11Cl2F2N3O
Target-Kategorie:
Phosphodiesterase (PDE)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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