(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models[1].
Molekulargewicht:
578.96
Reinheit:
98.46
CAS Nummer:
[2135640-93-4]
Formel:
C28H26ClF3N2O6
Target-Kategorie:
Dengue Virus,Flavivirus,Virus Protease
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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