AMG 837 calcium hydrate is an orally active, selective GPR40/FFA1 agonist with an EC50 of 1.5 nM against human GPR40. AMG 837 calcium hydrate stimulates insulin secretion in a glucose-dependent manner, and effectively improves glycemic control in both normal and diabetic rodent models. AMG 837 calcium hydrate binds to the BacA protein and impairs the survival and replication of Brucella. AMG 837 calcium hydrate can be used in research related to type 2 diabetes and brucellosis[1][2].
Molekulargewicht:
455.45
Reinheit:
99.00
CAS Nummer:
[1259389-38-2]
Formel:
C26H21F3O3.1/2Ca.H2O
Target-Kategorie:
Bacterial,Free Fatty Acid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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