Chk1-IN-6 is a selective and orally active Chk1 inhibitor with an IC50 of 16.1 nM. Chk1-IN-6 shows antiproliferative activity of MV-4-11 cells. Chk1-IN-6 exerts effective response in the MV-4-11 xenograft mouse model. Chk1-IN-6 exhibits synergistic anticancer effect with Gemcitabine (HY-17026). Chk1-IN-6 can be used in the research of cancers such as acute myeloid leukemia and colorectal adenocarcinoma[1].
Molekulargewicht:
365.36
Reinheit:
98.39
CAS Nummer:
[2428423-77-0]
Formel:
C16H18F3N7
Target-Kategorie:
Checkpoint Kinase (Chk)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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