NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3]. NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molekulargewicht:
473.52
Reinheit:
99.41
CAS Nummer:
[447415-26-1]
Formel:
C28H27NO6
Target-Kategorie:
Thyroid Hormone Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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