Tegaserod maleate (SDZ-HTF-919) is an orally active serotonin receptor 4 (HTR4, 5-HT4R) agonist and a 5-HT2B receptor antagonist. Tegaserod maleate has pKis of 7.5, 8.4 and 7.0 for human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors, respectively. Tegaserod maleate causes tumor cell apoptosis, blunts PI3K/Akt/mTOR signaling and decreases S6 phosphorylation. Tegaserod maleate has anti-tumor activity and has the potential for irritable bowel syndrome (IBS) research[1][2][3].
Molekulargewicht:
417.46
Reinheit:
99.90
CAS Nummer:
[189188-57-6]
Formel:
C20H27N5O5
Target-Kategorie:
5-HT Receptor,Apoptosis
Anwendungsbeschreibung:
MCE Product type: Reference compound
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