STAMBP-IN-1 is a small-molecule inhibitor of STAMBP deubiquitinase, and interrupts STAMBP-Ub-NALP7 interaction. STAMBP-IN-1 decreases protein level of its inflammasome substrate NALP7 and suppresses IL-1b release after Toll-like receptor (TLR) agonism. STAMBP-IN-1 inhibits the activity of STAMBP to cleave recombinant di-Ub with an IC50 value of 0.33 mM[1].
Molekulargewicht:
504.60
Reinheit:
98.73
CAS Nummer:
[896683-78-6]
Formel:
C27H28N4O4S
Target-Kategorie:
Deubiquitinase
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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