Acid Ceramidase-IN-1 is orally active and blood-brain barrier penetrant acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 µM). Acid Ceramidase-IN-1 reduces AC activity, accumulates ceramide species (Cer (d18:0/16:0), Cer (d18:1/16:0)), and decreases sphingosine levels. Acid Ceramidase-IN-1 can be used for the study of severe neurological lysosomal storage diseases (LSDs) such as Gauchers disease (GD) and Krabbes disease (KD)[1].
Molekulargewicht:
331.41
Reinheit:
99.36
CAS Nummer:
[2415225-30-6]
Formel:
C18H25N3O3
Target-Kategorie:
Ceramidase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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