Quizartinib dihydrochloride (AC220 dihydrochloride) is the dihydrochloride salt form of Quizartinib (HY-13001). Quizartinib dihydrochloride is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib dihydrochloride inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib dihydrochloride can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib dihydrochloride induces apoptosis[1][2][3].
Molekulargewicht:
633.59
Reinheit:
99.81
CAS Nummer:
[1132827-21-4]
Formel:
C29H34Cl2N6O4S
Target-Kategorie:
Apoptosis,FLT3,Ligands for Target Protein for PROTAC
Anwendungsbeschreibung:
MCE Product type: Reference compound
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