GNF2133 hydrochloride is a potent, selective and orally active DYRK1A inhibitor with IC50s of 0.0062, >50 µM for DYRK1A and GSK3beta, respectively. GNF2133 hydrochloride shows good proliferation potency and efficacy on rat and human primary beta-cell. GNF2133 hydrochloride significantly improves glucose disposal capacity and increases insulin secretion. GNF2133 hydrochloride has the potential for the research of type 1 diabetes[1].
Molekulargewicht:
470.99
Reinheit:
99.86
CAS Nummer:
[2561414-57-9]
Formel:
C24H31ClN6O2
Target-Kategorie:
DYRK
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
