Entacapone is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase (COMT) inhibitor. Entacapone inhibits COMT from rat brain, erythrocytes and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone is selective for COMT over other catecholamine metabolizing enzymes, including MAO-A, MAO-B, phenolsulphotransferase M (PST-M) and PST-P (IC50s>50 µM). Entacapone can be used for the research of Parkinsons disease[1]. Entacapone serves as a inhibitor of FTO demethylation with an IC50 of 3.5 µM, can be used for the research of metabolic disorders[2].
Molekulargewicht:
305.29
Reinheit:
99.97
CAS Nummer:
[130929-57-6]
Formel:
C14H15N3O5
Target-Kategorie:
COMT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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