PF15 is a PROTAC connected by ligands for FLT3 kinase and CRBN. PF15 is a high selective FLT3-ITD degrader, with a DC50 of 76.7 nM. PF15 significantly inhibits the proliferation of FLT3-ITD-positive cells, can down-regulate the phosphorylation of FLT3 and STAT5. PF15 also inhibits tumor growth in mouse models and can be used in study of leukemia[1].
Molekulargewicht:
855.94
CAS Nummer:
[2892631-70-6]
Formel:
C44H49N13O6
Target-Kategorie:
FLT3,PROTACs
Anwendungsbeschreibung:
MCE Product type: Reference compound
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