FT3967385 (FT385) is a selective covalent inhibitor that targets the outer mitochondrial membrane deubiquitinase (Deubiquitinase) USP30 (IC50 = 1.5 nM, Ki = 0.014 µM). By inhibiting the enzymatic activity of USP30, FT3967385 relieves its negative regulation of the PINK1-Parkin mediated mitochondrial ubiquitination cascade, thereby enhancing mitophagy. FT3967385 can be used for mechanistic studies of neurodegenerative diseases associated with mitochondrial dysfunction, such as Parkinsons disease[1][2][3].
Molekulargewicht:
373.41
Reinheit:
99.74
Formel:
C21H19N5O2
Target-Kategorie:
Deubiquitinase,PINK1/Parkin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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