Tinengotinib, CAS [[2230490-29-4]]

Produktübersicht

• Artikelname: Tinengotinib, CAS [[2230490-29-4]]
• Artikelnummer: MCE-HY-145601
• Hersteller Artikelnummer: HY-145601
• Alternativnummer: MCE-HY-145601-25MG,MCE-HY-145601-50MG,MCE-HY-145601-5MG,MCE-HY-145601-10MMX1ML,MCE-HY-145601-100MG,MCE-HY-145601-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: TT 00420

Produktbeschreibung

Tinengotinib (TT00420) is an orally active, spectrally selective small molecule kinase inhibitor targeting Aurora A/B (IC50=1.2-3.3 nM), FGFR1/2/3 (IC50=1.5-3.5 nM), VEGFRs, JAK1/2 and CSF1R. Tinengotinib blocks Aurora kinase-mediated cell cycle progression (inducing G2/M arrest), inhibits FGFR/JNK-JUN signaling pathway and activates MEK/ERK-dependent apoptotic pathway. Tinengotinib has the activity of anti-tumor proliferation, inducing apoptosis, inhibiting angiogenesis and regulating tumor microenvironment. Tinengotinib can be used in the study of triple-negative breast cancer (TNBC), gallbladder cancer and tumor immune microenvironment[1][2].

Produkteigenschaften

• Molekulargewicht: 394.86
• Reinheit: 99.57
• CAS Nummer: [2230490-29-4]
• Formel: C20H19ClN6O
• Target-Kategorie: Aurora Kinase,FGFR,VEGFR

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound