Zilebesiran (sodium), CAS [[2380166-34-5]] Preis auf Anfrage
Artikelnummer:
MCE-HY-145649A
Hersteller Artikelnummer:
HY-145649A
Alternativnummer:
MCE-HY-145649A-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
AD-85481 sodium, ALN-AGT sodium
Zilebesiran (AD-85481, ALN-AGT) sodium is a long-acting liver-targeted small interfering RNA (siRNA) antihypertensive agent. Zilebesiran sodium binds to the hepatic asialoglycoprotein receptor (ASGPR), activates the RNA-induced silencing complex to degrade hepatic angiotensinogen mRNA, thereby inhibiting the gene expression and synthesis of angiotensinogen. Zilebesiran sodium dose-dependently reduces serum angiotensinogen levels and 24-hour ambulatory blood pressure, with its effect persisting throughout the circadian cycle. Zilebesiran sodium is applicable to research related to hypertension[1][2].
