HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.
Molekulargewicht:
790.41
Reinheit:
98.76
CAS Nummer:
[2365478-58-4]
Formel:
C39H56ClN5O8S
Target-Kategorie:
Autophagy,PROTACs,SGK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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