ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53s transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases[1].
Molekulargewicht:
754.67
Reinheit:
99.91
CAS Nummer:
[2990065-87-5]
Formel:
C31H37F3N8O11
Target-Kategorie:
Apoptosis,MDM-2/p53
Anwendungsbeschreibung:
MCE Product type: Reference compound
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