XT2 is a potent, orally active, and selective inhibitor of NF-kappaB-inducing kinase (NIK) with an IC50 of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases[1]. XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molekulargewicht:
379.41
Reinheit:
99.60
CAS Nummer:
[2582816-37-1]
Formel:
C19H14FN5OS
Target-Kategorie:
NF-kappaB
Anwendungsbeschreibung:
MCE Product type: Reference compound
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