beta-S-ARCA, CAS [[1093268-63-3]] Preis auf Anfrage
Artikelnummer:
MCE-HY-145969
Hersteller Artikelnummer:
HY-145969
Alternativnummer:
MCE-HY-145969-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
Alternative Synonym:
3-O-Me-m7G(5)ppp(5)G
beta-S-ARCA (3-O-Me-m7G(5)ppp(5)G) is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. beta-S-ARCA binds eIF4E via electrostatic interactions between its beta-sulfur atom and positively charged Arg and Lys residues in the protein binding site. beta-S-ARCA prevents the decapping by Dcp2, increases the mRNA half-life, enhances cap-dependent translation, and increases protein expression in cells. beta-S-ARCA has been applied in researching experimental mRNA-based anticancer vaccines[1][2].
