NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin. NHEJ inhibitor-1 also induces ROS generation and MMP deduction[1].
Molekulargewicht:
848.79
Formel:
C30H35N7O8PtS
Target-Kategorie:
Reactive Oxygen Species (ROS)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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