Golcadomide (CC-99282) is a potent and orally active CRBN E3 ligase modulator (CELMoD). Golcadomide interacts with the CRL4 CRBN E3 ubiquitin ligase substrate receptor CRBN, inducing the recruitment and ubiquitin-mediated proteasomal degradation of the transcription factors Ikaros and Aiolos. Golcadomide shows potential for research in cancer-related fields, including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL)[1][2].
Molekulargewicht:
535.57
Reinheit:
98.04
CAS Nummer:
[2379572-34-4]
Formel:
C28H30FN5O5
Target-Kategorie:
Ligands for E3 Ligase,Molecular Glues
Anwendungsbeschreibung:
MCE Product type: Reference compound
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