Avacincaptad pegol (ARC1905) sodium is a 40KDa PEG-conjugated aptamer. Avacincaptad pegol sodium targets complement factor 5 (C5), inhibits the cleavage of C5 into C5a and C5b, limits inflammatory stimulation and complement membrane attack complex (MAC), and is used to study age-related macular degeneration (AMD). Avacincaptad pegol sodium limits irregular cell apoptosis by targeting downstream factors in the complement cascade while preserving the early steps of the complement system[1][2][3][4].
Molekulargewicht:
53500 (Approximately)
Reinheit:
94.64
CAS Nummer:
[1491144-00-3]
Formel:
C395H453F21N142Na39O262P39 (C2H4O)2n
Target-Kategorie:
Complement System
Anwendungsbeschreibung:
MCE Product type: Oligonucleotides
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