DC-TEAD3in03 is a subtype-selective and covalent TEAD3 inhibitor with an IC50 of 0.16 µM. DC-TEAD3in03 exhibits the inhibitory activity on TEAD1/2/4 reduced by more than 100 times. DC-TEAD3in03 has the IC50 for TEAD3 of 1.15 µM in the GAL4-TEAD reporter gene experiment in cells, and it does not interfere with the beta-catenin pathway. DC-TEAD3in03 reduces the growth rate of the zebrafish tail fin. DC-TEAD3in03 can be used to study the proportional growth of appendages in vertebrates[1].
Molekulargewicht:
288.38
Formel:
C17H24N2O2
Target-Kategorie:
YAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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