BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Abeta aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimers disease (AD) research[1].
Molekulargewicht:
438.24
CAS Nummer:
[2653349-78-9]
Formel:
C18H12BrN7O2
Target-Kategorie:
Amyloid-beta
Anwendungsbeschreibung:
MCE Product type: Reference compound
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