UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 (UCK2, a pyrimidine salvage enzyme) with an IC50 value of 16.6 µM. UCK2 can replace dihydroorotate dehydrogenase (DHODH), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC50s of 56 µM and 16 µM[1].
Molekulargewicht:
474.31
CAS Nummer:
[2376687-49-7]
Formel:
C19H13BrFN5O2S
Target-Kategorie:
DNA/RNA Synthesis
Anwendungsbeschreibung:
MCE Product type: Reference compound
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