SIRT2-IN-11 (AEM1) is a selective SIRT2 inhibitor with an IC50 value of 18.5 µM. SIRT2-IN-11 p53-dependently induces apoptosis, activates expression of CDKN1A, PUMA and NOXA, and increases acetylation of p53. SIRT2-IN-11 can be used for the research of p53-related cancers[1].
Molekulargewicht:
318.41
Reinheit:
99.94
CAS Nummer:
[1005095-06-6]
Formel:
C21H22N2O
Target-Kategorie:
Sirtuin
Anwendungsbeschreibung:
MCE Product type: Reference compound
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