12-Hydroxynevirapine (12-hydroxy-NVP, 12-OH-NVP) is a major oxidative metabolite of Nevirapine (HY-10570). Nevirapine is a non-nucleoside reverse transcriptase inhibitor indicated for the HIV-1 infections. Nevirapine causes idiosyncratic hepatotoxicity and mild-to-severe skin rashes. 12-Hydroxynevirapine, a non-reactive metabolite, can be bioactivated by sulphotransferases (SULTs) in the liver and skin, yielding the reactive species 12-Sulphoxy-nevirapine[1][2].
Molekulargewicht:
282.30
Reinheit:
96.04
CAS Nummer:
[133627-24-4]
Formel:
C15H14N4O2
Target-Kategorie:
Drug Metabolite
Anwendungsbeschreibung:
MCE Product type: Reference compound
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