dBRD 9-A, CAS [[2170679-42-0]]

Produktübersicht

• Artikelname: dBRD 9-A, CAS [[2170679-42-0]]
• Artikelnummer: MCE-HY-148739
• Hersteller Artikelnummer: HY-148739
• Alternativnummer: MCE-HY-148739-25MG,MCE-HY-148739-10MG,MCE-HY-148739-50MG,MCE-HY-148739-100MG,MCE-HY-148739-1MG,MCE-HY-148739-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

dBRD 9-A is a selective BRD9 PROTAC degrader. dBRD 9-A induces near complete BRD9 degradation dependent on E3 ubiquitin ligase CRBN and BRD9 bromodomain engagement, and drives loss of BRD9 chromatin binding genome-wide. dBRD 9-A downregulates oncogenic SS18-SSX-driven transcriptional programs, super enhancer-associated gene expression, and SS18-SSX1 super enhancer binding, and depletes GBAF complex members GLTSCR1/1L from SS18-SSX complexes. dBRD 9-A induces cell cycle arrest and increases apoptosis in synovial sarcoma cells. dBRD 9-A can be used for the research of synovial sarcoma[1].

Produkteigenschaften

• Molekulargewicht: 779.88
• Reinheit: 99.50
• CAS Nummer: [2170679-42-0]
• Formel: C42H49N7O8
• Target-Kategorie: Apoptosis,Epigenetic Reader Domain,PROTACs

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound