Zavondemstat (QC8222 free base, TACH 101 free base) is an orally active pan-KDM4 inhibitor, with a IC50 0.08 µM against human KDM4A-D and a K of 0.52 µM against human KDM4C. Zavondemstat induces cell apoptosis, causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer, esophageal squamous cell carcinoma and triple-negative breast cancer[1].
Molekulargewicht:
431.53
Reinheit:
99.29
CAS Nummer:
[1851412-93-5]
Formel:
C26H29N3O3
Target-Kategorie:
Apoptosis,Histone Demethylase
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
