PNU-183792, a 4-oxo-dihydroquinoline, is an orally active HSV polymerases inhibitor. PNU-183792 shows a broad-spectrum antiviral activity, with IC50 values of 0.69 µM, 0.37 µM and 0.58 µM for human cytomegalovirus (HCM), varicella zoster virus and HSV polymerases, respectively. PNU-183792 is inactive against human alpha, gamma and delta polymerases. PNU-183792 also inhibits simian varicella virus (SVV), murine cytomegalovirus (MCMV) and rat cytomegalovirus (RCMV)[1].
Molekulargewicht:
425.91
Reinheit:
98.88
CAS Nummer:
[282536-25-8]
Formel:
C23H24ClN3O3
Target-Kategorie:
HSV
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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