Rosolutamide, CAS [[1039760-91-2]]

Produktübersicht

• Artikelname: Rosolutamide, CAS [[1039760-91-2]]
• Artikelnummer: MCE-HY-149127
• Hersteller Artikelnummer: HY-149127
• Alternativnummer: MCE-HY-149127-5MG,MCE-HY-149127-1MG,MCE-HY-149127-10MG,MCE-HY-149127-25MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: ASC-JM17, ALZ-003

Produktbeschreibung

Rosolutamide (ASC-JM17), a curcumin analog, is an orally active, potent Nrf1 and Nrf2 activator. Rosolutamide activates Nrf1, Nrf2 and heat shock factor 1 (Hsf1), thereby activating the expression of proteasome subunits, antioxidant enzymes and molecular chaperones. Rosolutamide degrades the polyglutamine (polyQ) androgen receptor (AR) via the ubiquitin-proteasome pathway and improves motor function in mouse models of spinal and bulbar muscular atrophy (SBMA). Rosolutamide improves mitochondrial function and promotes autophagy, decreases mutant protein aggregates, and attenuates intracellular/mitochondrial reactive oxygen species (ROS) levels[1][2].

Produkteigenschaften

• Molekulargewicht: 464.55
• Reinheit: 99.03
• CAS Nummer: [1039760-91-2]
• Formel: C28H32O6
• Target-Kategorie: Androgen Receptor,HSP,Keap1-Nrf2,Mitophagy

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound