LSD1/TLK1-IN-1, CAS [[4734-59-2]]

Produktübersicht

• Artikelname: LSD1/TLK1-IN-1, CAS [[4734-59-2]]
• Artikelnummer: MCE-HY-149213
• Hersteller Artikelnummer: HY-149213
• Alternativnummer: MCE-HY-149213-100MG,MCE-HY-149213-10MG,MCE-HY-149213-50MG,MCE-HY-149213-25MG,MCE-HY-149213-5MG,MCE-HY-149213-10MMX1ML
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: J54, J3-54

Produktbeschreibung

LSD1/TLK1-IN-1 is an orally active LSD1, TLK1, TLK2, TTK inhibitor with an LSD1 IC50 of 0.247 µM. LSD1/TLK1-IN-1 suppresses phosphorylation of Nek1 at T141 and Rad9 at S328, abrogates the TLK1>Nek1>ATR>Chk1 axis, protects H3K4me1/2 from demethylation, and does not affect LSD2, MAO-A, or MAO-B. LSD1/TLK1-IN-1 induces apoptosis, bypasses cell-cycle arrest, suppresses tumor growth, acts as a weak D4R antagonist, downregulates PD-L1 expression, enhances T-cell killing response, inhibits gastric cancer cell proliferation, shows minimal toxicity, and has no significant effect on normal prostate cells. LSD1/TLK1-IN-1 can be used for the research of prostate cancer and gastric cancer[1][2].

Produkteigenschaften

• Molekulargewicht: 312.43
• Reinheit: 99.20
• CAS Nummer: [4734-59-2]
• Formel: C18H20N2OS
• Target-Kategorie: Histone Demethylase,TLK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound