USP28-IN-4 is a USP28 inhibitor (IC50=0.04 µM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1].
Molekulargewicht:
461.36
Reinheit:
99.35
CAS Nummer:
[2931509-15-6]
Formel:
C22H18Cl2N2O3S
Target-Kategorie:
Deubiquitinase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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