FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226, or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp[1].
Molekulargewicht:
415.48
Reinheit:
99.86
CAS Nummer:
[1807320-40-6]
Formel:
C26H25NO4
Target-Kategorie:
P-glycoprotein
Anwendungsbeschreibung:
MCE Product type: Reference compound
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