Migalastat (GR181413A free base) hydrochloride is an orally active alpha-galactosidase A molecular chaperone, with an IC50 value of 0.04 µM for human alpha-Gal A. Migalastat binds to the active site of certain unstable mutant forms of alpha-galactosidase A, facilitating their transport to the lysosome. After dissociation in the acidic environment, Migalastat enables the mutant alpha-galactosidase A to exhibit biological activity[1].
Molekulargewicht:
199.63
Reinheit:
99
CAS Nummer:
[75172-81-5]
Formel:
C6H14ClNO4
Target-Kategorie:
Glycosidase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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