IHMT-IDH1-053, CAS [[3049485-80-2]] Preis auf Anfrage

Produktübersicht

• Artikelname: IHMT-IDH1-053, CAS [[3049485-80-2]] Preis auf Anfrage
• Artikelnummer: MCE-HY-149359
• Hersteller Artikelnummer: HY-149359
• Alternativnummer: MCE-HY-149359-1UNIT
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

IHMT-IDH1-053 (compound 16) is a highly selectivity and irreversible IDH1-mutant inhibitor with an IC50 of 4.7 nM for IDH1 R132H. IHMT-IDH1-053 displays high selectivity against IDH1 mutants over IDH1 wt and IDH2 wt/mutants. IHMT-IDH1-053 inhibits 2-hydroxyglutarate (2-HG) production in IDH1 R132H mutant transfected 293T cells (IC50=28 nM). IHMT-IDH1-053 binds to the IDH1 R132H protein in the allosteric pocket adjacent to the NAPDH binding pocket through a covalent bond with residue Cys269. IHMT-IDH1-053 inhibits the proliferation of HT1080 cell line and primary AML cells which both bear IDH1 R132 mutants[1].

Produkteigenschaften

• Molekulargewicht: 532.63
• CAS Nummer: [3049485-80-2]
• Formel: C25H33FN6O4S
• Target-Kategorie: Isocitrate Dehydrogenase (IDH)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound