ICMT-IN-35 (compound 10n) is a FTPA-triazole compound and ICMT inhibitor (IC50=0.8 µM). ICMT-IN-35 is taken up by mammalian cells and can prevent K-Ras membrane localization and induce K-Ras mislocalization. Furthermore, ICMT-IN-35 is selectively cytotoxic against ICMT+/+ MEF cells and has low micromolar activity (IC50=0.8 µM) against metastatic pancreatic cancer cell lines[1].
Molekulargewicht:
435.58
Formel:
C25H29N3O2S
Target-Kategorie:
ICMT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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